June 4/Pharma Investments, Ventures & Law Weekly -- According to a study from Toronto, Canada, "In cohort studies, insoluble fiber has been associated with a reduced risk of obesity and diabetes; however, compared with soluble fiber, its role in the regulation of short-term food intake (FI) and satiety has received little attention. Our aim was to compare the effects of a high-insoluble-fiber (HF) cereal with a low-fiber (LF) cereal on FI, subjective appetite (SA), and plasma glucose (PG) in healthy individuals."
"Males and females (n = 32) were randomly assigned to consume 60g of either HF (26g insoluble fiber, 120 kcal) or LF (1g fiber, 217 kcal) breakfast cereal. Pre- and postlunch SA and PG were measured regularly for 4 hours, and ad libitum FI was measured at 3 hours. The prelunch SA area under the curve did not differ between the two cereals, but when expressed as change in appetite per kilocalorie of cereal, HF suppressed SA more than did LF (-17.6 +/- 1.8 compared with -10.0 +/- 1.1 mm. min. kcal(-1), respectively; P< 0.01). Lunchtime FI did not differ between cereals, but cumulative energy intake (cereal 1 lunch) was lower after the HF than after the LF cereal (1330 +/- 57 compared with 1422 +/- 66 kcal, respectively; P = 0.01).