May 11/London/Lipids in Health and Disease -- Environmental stress plays an important role in the development of glucose intolerance influencing lipid and glucose metabolism through sympathetic nervous system, cytokines and hormones such as glucocorticoids, catecholamines and glucagon. Otherwise, fish oil prevents glucose intolerance and insulin resistance.
Although the mechanisms involved are not fully understood, it is known that sympathetic and HPA responses are blunted and catecholamine and glucocorticoid concentrations can be modulated by fish consumption. The aim of the present study was to evaluate whether fish oil, on a normal lipidic diet: 1) could prevent the effect of footshock-stress on the development of glucose intolerance; 2) modified adiponectin receptor and serum concentration; and 3) also modified TNF-alpha, IL-6 and interleukin-10 (IL-10) levels in adipose tissue and liver.