Creo, an ingredient company with a proprietary platform for producing natural rare cannabinoids without the cannabis plant, announced it has produced cannabigerol (CBG) and cannabigerolic acid (CBGA) through fermentation at 12,500-liter scale, with performance matching or exceeding expectations.
Rare cannabinoids such as CBG and CBGA are being studied for a range of potential benefits, but they're only found in small quantities in the plant and can be challenging to extract, making CBGA hard to produce at scale.
To enable broader access to CBGA, Creo has partnered with biotech industry-leader Genomatica to create a patented fermentation technology platform that produces high-quality rare cannabinoids, sustainably, at scale, and at a higher purity level than traditional methods. Commercial production and supply are expected to begin in the second quarter of 2021.
"With this demo run, Creo has cemented its leadership position in the emerging market for fermentation-based cannabinoids," said Creo CEO Roy Lipski. "This is a very significant milestone for Creo and a major step towards enabling cannabinoid ingredients to reach every household, through wellness, beauty, food and beverage products."
According to a recent report on cannabinoids and the bio revolution by Raymond James, a financial services firm, the global market for cannabinoids produced by fermentation is estimated to grow from $10 billion in 2025 to $115 billion by 2040.
"We're excited to be with Creo at the forefront of innovation in this fast-moving industry," said Nelson Barton, senior VP, research and development, Genomatica. "We're glad to have demonstrated, yet again, Genomatica's expertise in driving fermentation-based processes from idea to commercial readiness and to showcase our technology delivering another performance product in health and wellness."
Creo's cannabinoids are produced in the U.S. in an FDA registered, food cGMP-compliant facility. Creo's global manufacturing partner has more than 4,000 scientists, research chemists, engineers and plant operators dedicated to delivering for customers in a wide range of consumer and industrial markets.
Creo's promise of greater sustainability is why it makes its cannabinoid ingredients using one of the world's oldest natural processes — fermentation. Fermentation requires less water, energy and land than the plant-based approaches typically used to extract cannabinoid ingredients.