September 1/Boston/Life Science Weekly -- A new study, "Fructose and Saturated Fats Predispose Hyperinsulinemia in Lean Male Rat Offspring," is now available. "Early exposure to suboptimal nutrition during perinatal period imposes risk to metabolic disorders later in life. Fructose intake has been associated with increases in de novo lipogenesis, dyslipidemia, insulin resistance, and obesity," researchers in the U.S. report.
"Excess consumption of saturated fat is associated with metabolic disorders. The objective of this animal study was to investigate morphological, metabolic and endocrine phenotypes of male offspring born to dams consuming diets containing either 30% fructose, 9.9% coconut fat and 0.5% cholesterol (F + SFA) or 30% glucose, and 11% corn oil (C), one month before conception and during gestation and nursing. Proven male and female Sprague Dawley breeders were fed ad libitum with either F + SFA or C diet throughout the study. At weaning, five male pups from each group were sacrificed for determining morphological phenotypes. The other five male offspring from each group were rehabilitated to the C diet for an additional 12 weeks.