Fiber and Colon Tumor Reduction in Rats
May 6/Food & Farm Week -- "Certain dietary fibers have been shown to reduce the incidence of colon tumors in rats fed high-fat diets. Although insoluble fibers are most commonly associated with this anticancer potential, certain soluble fibers, Such as psyllium, flaxseed and soybean, have also been shown to inhibit chemically induced colon cancer in rodents," scientists writing in the journal Cereal Foods World report.
"The main purpose of this research was to evaluate the effect of wheat bran, flaxseed and soybean alone and in combination on azoxymethane-induced colon tumorigenesis in Fisher-344 rats maintained on high-fat diets. A total of 165 male Fisher-344 rats was divided into 11 test diet groups. After three weeks on test diets, the rats were given injections of ethane AOM (15mg/kg of body weight) and remained on their respective experimental diets until killed by exsanguination under anesthesia at week 10. The colons were removed and prepared for evaluation of colonic aberrant crypt formations (ACF). Results indicate that both insoluble (wheat bran) in various combinations with soluble (soy, flax) fibers significantly reduced both the number and size of ACE. The soybean diet resulted in a significant decrease (p<0.05) in the number of ACF compared with wheat bran or flax," wrote C.L. Nochera and colleagues, Grand Valley State University.
The researchers concluded, "ACF incidence and multiplicities were significantly reduced (p<0.05) in dietary groups including flax and wheat bran fiber in combination with soybean."
Nochera and colleagues published their study in Cereal Foods World ("Dietary Combinations of Wheat Bran, Flax and Soy Reduce ACF in Rat Model." Cereal Foods World, 2009;54(2):66-69).
Additional information can be obtained by contacting C.L. Nochera, Grand Valley State University, Dept. of Biomedical Science, 257 PAD, Allendale, MI 49401.
From the May 11, 2009, Prepared Foods E-dition