Studies on guinea pigs show dramatic changes in the cholesterol accumulation caused by high-fat diets with the inclusion of grape seed extract. A powerful antioxidant, grape seed has a significant effect on atherosclerosis. The extract used in the studies, from Polyphenolics, a division of Constellation Wines U.S., has an ORAC value 1,000 times higher than that of grape juice. Polyphenolics' grape seed extract is made from unfermented grapes using a patented, solvent-free water extraction method. Polyphenolics,