The Efficacy of Green Coffee Extract
The efficacy of green coffee extract to impact on an independent risk factor for cardiovascular heart disease has been proven ineffective.
The risk factor, endothelial dysfunction (ED), has also been associated with metabolic syndrome and type 2 diabetes, both disorders increasing rapidly in Australia.
UWA School of Medicine & Pharmacology’s Natalie Ward says there is epidemiological evidence to suggest increased coffee consumption may be protective against cardiovascular disease (CVD) and its risk factors, particularly type 2 diabetes.
“This study was designed to investigate whether green coffee bean extract could protect against the development of the metabolic syndrome, a cluster of CVD risk factors, as well as study the mechanisms involved in this process,” Ward says.
Thirty C57BL6 mice were divided into three groups of 10 and fed a normal diet, a HFD, and HFD with 0.5% w/w green coffee bean extract (GCE).
The mice fed a HFD and HFD + GCE were found to display obesity, glucose intolerance, insulin resistance and oxidative stress, all symptoms of the metabolic syndrome.