June 7/Basel, Switzerland/Press Release -- A new study shows that long-term L-Carnitine supplementation in the form of Carnipure&trade; tartrate manufactured by Lonza coupled with the intake of carbohydrates increases muscular L-Carnitine content in recreational athletes. The randomized, double-blind, placebo-controlled study was conducted by the School of Biomedical Sciences at the University of Nottingham Medical School in England and published in the <em>Journal of Physiology</em> (589.4 (2011) pp 963-973).</p>

This is the first study in healthy humans showing that muscle L-Carnitine content can be influenced by dietary means and that L-Carnitine plays a dual role in skeletal muscle fuel metabolism during exercise that is dependent on exercise intensity,&rdquo; comments Professor Paul Greenhaff, lead author of the study. During low intensity exercise increasing muscle L-Carnitine content led to glycogen sparing and increased fatty acid oxidation. In high intensity exercise it led to a decrease in anaerobic energy production, including a decrease in muscle lactate accumulation. Furthermore, during a performance test, L-Carnitine supplementation resulted in lower perceived exertion as well as increased work output. This novel technology is protected by a patent application WO/2004/082674 owned by the University of Nottingham.</p>
Previous studies show that Carnipure&trade; tartrate supplementation can increase fatty acid oxidation in a non-athletic population. The current study is the first to show the same effect in recreational athletes. These findings together with previous findings demonstrate that Carnipure&trade; supplementation may lead to a decrease in the production of free radicals, less tissue damage and reduced muscle soreness after exercise. &nbsp;Carnipure&trade; supplementation can play an important role for sports nutrition supporting both exercise performance as well as the subsequent recovery process.</p>
L-Carnitine, a nutrient produced in the body and found in dietary sources, plays a critical role in fat and energy metabolism. It shuttles long-chain fatty acids into the cells&rsquo; mitochondria where they are broken down for energy generation, as well as maintaining muscle carbohydrate oxidation and offsetting lactate production during intense exercise. Extensive research shows that supplementary Carnipure&trade; may play a supportive role in many areas of health, including cardiovascular health, weight management and healthy aging. Carnipure&trade; is easily integrated into dietary supplements and functional foods and beverages.