March 2011 -Glutathione is an endogenously produced compound that protects the body against the bombardment of free radicals. Free radicals attack the polyunsaturated fatty acids (PUFA) in the cell membranes of tissues. PUFA oxidation occurs via a free radical chain mechanism that proceeds through several stages leading to a series of complex chemical changes. PUFAs will lose a hydrogen atom from their backbone and produce “free radicals” which then react with oxygen to form peroxides, which then attack a new lipid molecule. This can lead to tissue damage and is often associated with age-related cellular damage.