April 28/Washington/Hindustan Times -- Excessive intake of aspartame may stall the ability of brain enzymes to work normally, say scientists.

A new review by researchers from the University of Pretoria and the University of Limpopo has revealed that high doses of the sweetener may lead to neurodegeneration.

The review also revealed that high dosage of aspartame can extensively disturb the metabolism of amino acids, protein structure and metabolism, the integrity of nucleic acids, neuronal function and endocrine balances in the brain, reports Environmental News Network.

Moreover, aspartame breakdown can compel nerves to fire excessively that can indirectly lead to a high rate of neuron depolarisation.

Neither the European Food Safety Authority (EFSA) or the U.S. Food and Drug Administration (FDA) have modified their guidelines regarding the safety of the ingredient or intake advice.

From the May 12, 2008, Prepared Foods e-Flash